IL6;IL-6 Protein, Human, Recombinant  白細(xì)胞介素- 6 (il - 6)是一種多功能α-螺旋細(xì)胞因子.

惠誠生物提供IL6 以及各類細(xì)胞因子，同時推出CHO穩(wěn)定細(xì)胞株開發(fā)技術(shù)服務(wù)方案，詳情咨詢電話021-60498804.

IL-6 Background Information

Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. It exerts actions through the its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 13 (gp13) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.,

IL-6 Background Information:

Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. It exerts actions through the its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 13 (gp13) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.,

產(chǎn)品說明：

白細(xì)胞介素-6簡稱白介素6 (IL-6),屬于白細(xì)胞介素的一種細(xì)胞因子。它是由纖維母細(xì)胞、單核/巨噬細(xì)胞、T淋巴細(xì)胞、B淋巴細(xì)胞、上皮細(xì)胞、角質(zhì)細(xì)胞、以及多種瘤細(xì)胞所產(chǎn)生。IL-1、TNF-a, PDGF、病毒感染、雙鏈RNA及c AMP等，均可誘導(dǎo)正常細(xì)胞產(chǎn)生白介素-6。白介素6能夠刺激參與免疫反應(yīng)的細(xì)胞增殖、分化并提高其功能。它可誘導(dǎo)B細(xì)胞分化、支持漿細(xì)胞瘤和骨髓瘤增生、誘導(dǎo)單核細(xì)胞分化；增強NK細(xì)胞活性、誘導(dǎo)急性期反應(yīng)分子并刺激肝細(xì)胞、誘導(dǎo)神經(jīng)元分化。

本產(chǎn)品由真核細(xì)胞表達(dá)的重組蛋白，是將蛋白基因接入穩(wěn)定表達(dá)載體，轉(zhuǎn)化CHO-K1細(xì)胞，經(jīng)克隆篩選，質(zhì)量驗證，挑選的穩(wěn)定表達(dá)株，由化學(xué)成分確定的培養(yǎng)基（不含有任何動物源成分）發(fā)酵制備，工藝穩(wěn)定，保證了產(chǎn)品質(zhì)量及批次間的一致性。

本產(chǎn)品為無菌凍干粉劑，由含有10mMPBS pH為7.2的蛋白溶液經(jīng)0.2μm過濾后分裝凍干。

規(guī)格參數(shù): 50μg/1mg
生物學(xué)活性：比活性大于1.0 x 107IU/mg
純      度：經(jīng)高效液相色譜（SEC-HPLC）和SDS-PAGE檢測，純度大于95.0%
內(nèi)  毒  素：小于5EU/mg

使用說明:
建議將凍干rhIL-6溶解在注射用水或滅菌的超純水中，濃度不低于100μg/ml，以待進(jìn)一步稀釋至工作濃度。盡可能避免反復(fù)凍融。
復(fù)溶后的細(xì)胞因子：4℃可穩(wěn)定儲存7-10天；長期保存請分裝后存放于-20℃。
本產(chǎn)品白介素IL6僅供研究使用/For Research Use Only.

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